Frédéric Dollé Selected Research

N,N- diethyl- 2- (2- (4- (2- fluoroethoxy)phenyl)- 5,7- dimethylpyrazolo(1,5- a)pyrimidin- 3- yl)acetamide

1/2022	Direct Comparison of [18F]F-DPA with [18F]DPA-714 and [11C]PBR28 for Neuroinflammation Imaging in the same Alzheimer's Disease Model Mice and Healthy Controls.
1/2020	TSPO imaging-guided characterization of the immunosuppressive myeloid tumor microenvironment in patients with malignant glioma.
3/2017	PET imaging of cannabinoid type 2 receptors with [11C]A-836339 did not evidence changes following neuroinflammation in rats.
2/2016	Evaluation of PET Imaging Performance of the TSPO Radioligand [18F]DPA-714 in Mouse and Rat Models of Cancer and Inflammation.
1/2016	6-hydroxydopamine-induced Parkinson's disease-like degeneration generates acute microgliosis and astrogliosis in the nigrostriatal system but no bioluminescence imaging-detectable alteration in adult neurogenesis.
1/2016	PET Imaging with [(18)F]FSPG Evidences the Role of System xc(-) on Brain Inflammation Following Cerebral Ischemia in Rats.
11/2015	Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke.
2/2015	In vivo evaluation of inflammatory bowel disease with the aid of μPET and the translocator protein 18 kDa radioligand [18F]DPA-714.
5/2014	[18F]DPA-C5yne, a novel fluorine-18-labelled analogue of DPA-714: radiosynthesis and preliminary evaluation as a radiotracer for imaging neuroinflammation with PET.
3/2014	[¹⁸F]DPA-714 as a biomarker for positron emission tomography imaging of rheumatoid arthritis in an animal model.

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Frédéric Dollé Research Topics

Disease

25	Neuroinflammatory Diseases 01/2022 - 04/2007
9	Parkinson Disease (Parkinson's Disease) 01/2019 - 04/2002
8	Neoplasms (Cancer) 01/2020 - 03/2005
7	Inflammation (Inflammations) 01/2022 - 05/2010
6	Breast Neoplasms (Breast Cancer) 02/2016 - 03/2011
5	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2017 - 04/2007
4	Glioma (Gliomas) 01/2020 - 10/2010
4	Stroke (Strokes) 01/2018 - 01/2010
3	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 06/2005
3	Brain Ischemia (Cerebral Ischemia) 03/2017 - 01/2010
3	Multiple Sclerosis 05/2016 - 04/2011
3	Ischemia 01/2016 - 01/2010
3	Melanoma (Melanoma, Malignant) 03/2015 - 04/2011
2	Brain Diseases (Brain Disorder) 01/2016 - 12/2008
2	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2016 - 11/2015
2	Dyskinesias (Dyskinesia) 01/2014 - 01/2013
1	Cancer Pain 11/2017
1	Brain Neoplasms (Brain Tumor) 02/2016
1	Carcinogenesis 01/2016
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 02/2015
1	Rheumatoid Arthritis 03/2014
1	Disease Progression 12/2013
1	Huntington Disease (Huntington's Disease) 03/2013
1	AIDS-Related Complex (ARC) 01/2013
1	Myelitis 04/2012
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 04/2012
1	Encephalitis (Encephalitis, Rasmussen) 02/2012
1	Amyloid Plaque 04/2011

Drug/Important Bio-Agent (IBA)

28	Proteins (Proteins, Gene)FDA Link 01/2020 - 03/2005
16	N,N- diethyl- 2- (2- (4- (2- fluoroethoxy)phenyl)- 5,7- dimethylpyrazolo(1,5- a)pyrimidin- 3- yl)acetamideIBA 01/2022 - 01/2010
11	Biomarkers (Surrogate Marker)IBA 12/2018 - 12/2008
10	LigandsIBA 01/2016 - 09/2002
9	GABA-A Receptors (GABA(A) Receptor)IBA 03/2013 - 04/2007
7	acetamideIBA 01/2016 - 04/2007
4	Pharmaceutical PreparationsIBA 01/2017 - 12/2008
4	PK 11195 (PK11195)IBA 05/2010 - 04/2007
3	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 02/2016 - 03/2011
3	Levodopa (L Dopa)FDA LinkGeneric 01/2014 - 01/2010
2	Oxidopamine (6 Hydroxydopamine)IBA 01/2019 - 01/2016
2	Carbon-11IBA 01/2018 - 11/2017
2	CannabinoidsIBA 11/2017 - 03/2017
2	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA 03/2017 - 08/2011
2	Glucose (Dextrose)FDA LinkGeneric 01/2016 - 02/2015
2	Dopamine (Intropin)FDA LinkGeneric 01/2016 - 01/2014
2	Fluorine-18IBA 09/2015 - 03/2014
2	Radioisotopes (Radionuclides)IBA 03/2015 - 04/2011
2	Melanins (Melanin)IBA 03/2015 - 09/2012
2	ATP-Binding Cassette Transporters (ABC Transporters)IBA 11/2013 - 10/2013
2	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2013 - 07/2004
2	2- (6- chloro- 2- (4- iodophenyl)- imidazo(1,2- alpha)pyridin- 3- yl)- N- ethyl- N- methyl- acetamideIBA 05/2010 - 11/2007
2	Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA 03/2006 - 08/2002
1	ethyl tyrosine esterIBA 01/2020
1	HLA Antigens (Human Leukocyte Antigens)IBA 01/2020
1	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 01/2020
1	gamma-glutamylaminomethylsulfonic acid (GAMS)IBA 01/2020
1	HLA-DR Antigens (HLA-DR)IBA 01/2020
1	Interleukin-4 (Interleukin 4)IBA 01/2018
1	A-836339IBA 11/2017
1	1,1-dimethylbutyl-1-deoxy-Delta(9)-THCIBA 03/2017
1	CB2 Cannabinoid ReceptorIBA 03/2017
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2016
1	N- (8- aminohexyl)- 5- iodonaphthalene- 1- sulfonamide (W8)IBA 01/2016
1	Sulfasalazine (Azulfidine)FDA LinkGeneric 01/2016
1	AntiportersIBA 01/2016
1	Docetaxel (Taxotere)FDA Link 01/2016
1	Cystine (L-Cystine)IBA 01/2016
1	Oncogene Proteins (Oncogene Protein)IBA 01/2016
1	ArginaseIBA 01/2016
1	Glutamic Acid (Glutamate)FDA Link 01/2016
1	Matrix Metalloproteinases (MMPs)IBA 11/2015
1	Flumazenil (Romazicon)FDA LinkGeneric 10/2015
1	BenzodiazepinesIBA 10/2015
1	PyrimidinesIBA 09/2015
1	Biological ProductsIBA 09/2015
1	F 4 (F-4)IBA 03/2015
1	N- (2- diethylaminoethyl)- 6- iodoquinoxaline- 2- carboxamideIBA 03/2015
1	Trinitrobenzenesulfonic AcidIBA 02/2015
1	Dextrans (Dextran)FDA Link 02/2015
1	Molecular Probes (Molecular Probe)IBA 02/2015
1	sodium sulfate (sodium bisulfate)FDA LinkGeneric 02/2015
1	N,N- diethyl- 2- (2- (4- (3- fluoropent- 1- yn- 1- yl)phenyl)- 5,7- dimethylpyrazolo(1,5- a)pyrimidin- 3- yl)acetamideIBA 03/2014
1	Dihydrotachysterol (AT 10)IBA 03/2014
1	Dopamine Receptors (Dopamine Receptor)IBA 01/2014
1	erucylphospho- N,N,N- trimethylpropylammoniumIBA 12/2013
1	Glial Fibrillary Acidic ProteinIBA 12/2013
1	Sodium Channel BlockersIBA 01/2013
1	Messenger RNA (mRNA)IBA 01/2013
1	IRC-082451IBA 01/2013
1	BN82451IBA 01/2013
1	AntioxidantsIBA 01/2013
1	Cyclooxygenase InhibitorsIBA 01/2013
1	pyridineIBA 09/2012
1	Myelin Basic ProteinIBA 04/2012
1	AntibodiesIBA 06/2011
1	thioflavin TIBA 04/2011
1	6-hydroxybenzothiazoleIBA 04/2011
1	indoleacetamideIBA 03/2011

Therapy/Procedure

11	Therapeutics 01/2020 - 07/2006
1	Drug Therapy (Chemotherapy) 01/2016
1	Treatment Delay 01/2016